中央社 2010/12/09
美國科學家首創以幹細胞技術從2隻雄性老鼠身上孕育出幼鼠，科學家表示這項新突破可幫助保育瀕臨絕種的動植物，甚至有一天能幫助人類同性情侶擁有自己血緣基因的孩子。
據今天刊載於生殖科學期刊（journal Biology of Reproduction）的研究表示，德州再生科學家成功操控雄性（XY染色體）老鼠胚胎細胞，發展出「誘發性多功能性幹細胞」（induced pluripotent stem cells,iPS）細胞株。
這些「誘發性多功能性幹細胞」就是所謂已接受過基因重編，以便成為類胚胎幹細胞狀態的成人細胞。
部分從新細胞株成長出來的細胞會直接失去Y染色體，成為XO細胞。
這些XO細胞注入到雌性老鼠胚胎並移植到代理孕鼠體內後，就會生下帶有原先雄性老鼠X染色體的幼鼠。
這些幼鼠長大與正常的雄性鼠交配後，生下的幼鼠無論雄性或雌性，都帶有原先2位鼠爸爸的基因。
這份研究是由美國德州大學的癌症治療中心（MD Anderson Cancer Center）研究員所執行。（譯者：中央社陳禹安）
※ 相關報導：
＊ Reproduction Hack Makes Mice From Two Dads
http://www.wired.com/wiredscience/2010/12/two-dad-mice/
In a weird feat of biotechnological virtuosity, scientists have engineered mice with genes from two dads, and none from a mom.
＊ Generation of Viable Male and Female Mice from Two Fathers
http://www.biolreprod.org/content/early/2010/12/07/biolreprod.110.088831.abstract
Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang,＊ 科學家證明刪除 1 個基因使哺乳類動物再生
M. David Stewart, Hongran Wang, Austin J. Cooney and
Richard R. Behringer
Biology of Reproduction
Published online before print December 8, 2010
doi: 10.1095/biolreprod.110.088831
In sexual species, fertilization of oocytes produces individuals with alleles derived from both parents. Here we use pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. Male (XY) mouse induced pluripotent stem (iPS) cells (Father #1) were used to isolate subclones that had spontaneously lost the Y chromosome to become genetically female (XO). These male-derived XO stem cells were used to generate female chimeras that were bred with genetically distinct males (Father #2), yielding progeny possessing genetic information that was equally derived from both fathers. Thus, functional oocytes can be generated from male somatic cells after reprogramming and spontaneous sex reversal. These findings have novel implications for mammalian reproduction and assisted reproductive technology.
＊ 科學家發現老化關鍵路徑（Sirt3）
＊ 提高癌患存活 從基因轉移+幹細胞著手
＊ 美用人類胚胎幹細胞 醫療病患
沒有留言:
張貼留言